- Titre : Extra virgin olive oil polyphenols improve hematological parameters and mineral profile disorders in rats exposed to a high dose of acrylamide
- DOI: 10.71751/JAAOGv1i2y2022-59-67
- Auteur : Imen GHORBEL; Mariem Chaabane; Choumous Kallel; Najiba ZEGHAL; Naziha GRATI KAMMOUN
- Abstract : Our study investigated the protective efficacy of extra virgin olive oil polyphenols against disorders in blood hematological parameters and mineral profile in rats exposed to a high dose of acrylamide.
Animals were divided into four groups of six each: group 1, serving as controls, received distilled water; group 2 received ACR (50 mg/kg body weight) by gavage; group 3 received both acrylamide and olive oil polyphenols (1ml) by gavage; group 4 received only polyphenols (1 ml) by gavage for 3 weeks.
ACR-treated group showed significant differences in several hematological parameters including red and white blood cellscount, hemoglobin concentration, hematocrit value and platelet count. Moreover, there were changes in the plasma levels of some minerals such as iron, calcium and magnesium,while the phosphorus levels remained unchanged when compared to those of the control group. Supplementation of olive oil polyphenols restored changes in blood hematological and mineral profiles to near normal values. In conclusion, polyphenols might act as protective agents in preventing ACR-induced disturbances in bloodcell parameters and mineral profile. - Pagination : 59-67
